Determination of urokinase-type plasminogen activator serum levels in healthy and oncologic cats.

Autor:	Viegas C; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., de Matos AJ; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., Leite-Martins LR; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., Viegas I; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., Ferreira RRF; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., Gregório H; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório)., Santos AA; Department of Veterinary Clinics, Faculty of Veterinary Medicine, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisbon, Portugal (Viegas C, Viegas I); Animal Blood Bank, R. de João de Deus 741, Porto, Portugal (Ferreira); Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar, University of Porto, R. Jorge Viterbo Ferreira 228, Porto, Portugal (de Matos, Leite-Martins, Santos); Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute, P. Gomes Teixeira, Porto, Portugal (de Matos, Santos); Centro Hospitalar Veterinário, Porto, Portugal (Gregório).
Jazyk:	angličtina
Zdroj:	Canadian journal of veterinary research = Revue canadienne de recherche veterinaire [Can J Vet Res] 2020 Jan; Vol. 84 (1), pp. 60-66.
Abstrakt:	The urokinase plasminogen activator system (uPAS) has been poorly investigated in veterinary oncology. The aim of this study was to determine uPA serum concentrations in healthy and oncologic cats to understand the potential value of uPA as a cancer biomarker. Serum samples were collected from 19 healthy cats and 18 cats with spontaneous malignant neoplasms and uPA was measured through a specific enzyme-linked immunosorbent assay kit. The differences between uPA values and their relation with intrinsic factors and clinicopathological parameters were analyzed using an analysis of variance (ANOVA) and independent t -test. The average serum concentration of uPA in cancerous cats (0.54 ± 0.22 ng/mL) differed from that of healthy cats (1.10 ± 1.16 ng/mL) but was not significantly influenced by cats' clinicopathological parameters or by the presence of metastases. This study describes, for the first time, the serum concentrations of uPA in cats and proposes directions for future studies to uncover the relevance of uPAS in feline carcinogenesis. (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)
Databáze:	MEDLINE
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