Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

Autor: King C; Department of Women and Child's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, England., McKenna A; Department of Women and Child's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, England., Farzan N; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Vijverberg SJ; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., van der Schee MP; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Maitland-van der Zee AH; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands., Arianto L; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., BØnnelykke K; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Berce V; Department of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia.; Centre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia., PotoČnik U; Centre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia., Repnik K; Centre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia., Carleton B; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, BC Children's Hospital and Research Institute, Vancouver, Canada., Daley D; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, BC Children's Hospital and Research Institute, Vancouver, Canada., Chew FT; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore., Chiang WC; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore., Sio YY; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore., Cloutier MM; Asthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, Farmington, Connecticut, USA., Den Dekker HT; Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Duijts L; Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., de Jongste JC; Department of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands., Dijk FN; Department of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.; Groningen Research Institute for Asthma & COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Flores C; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.; Genomics Division, Instituto Tecnológico y de Energías Renovables (ITER), Santa Cruz de Tenerife, Spain., Hernandez-Pacheco N; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain., Mukhopadhyay S; Academic Department of Paediatrics, Brighton & Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK., Basu K; Academic Department of Paediatrics, Brighton & Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK., Tantisira KG; The Channing Division of Network Medicine, Department of Medicine, Boston, MA, 02115, USA.; Division of Pulmonary & Critical Care Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, MA, 02115, USA., Verhamme KM; Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Celedón JC; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Forno E; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Canino G; Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico., Francis B; Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, England., Pirmohamed M; Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, England., Sinha I; Department of Respiratory Medicine, Alder Hey Children's Hospital, Liverpool, England., Hawcutt DB; Department of Women and Child's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, England. d.hawwcutt@liverpool.ac.uk.; NIHR Alder Hey Clinical Research Facility, Alder Hey Children's Hospital, Liverpool, England. d.hawwcutt@liverpool.ac.uk.
Jazyk: angličtina
Zdroj: The pharmacogenomics journal [Pharmacogenomics J] 2020 Oct; Vol. 20 (5), pp. 621-628. Date of Electronic Publication: 2020 Jan 17.
DOI: 10.1038/s41397-019-0140-y
Abstrakt: A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.
Databáze: MEDLINE