Frequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes in Argentina.

Autor:	Taverna CG; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: ctaverna@anlis.gov.ar., Bosco-Borgeat ME; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina., Mazza M; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina., Vivot ME; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina., Davel G; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina., Canteros CE; Mycology Department, INEI (Instituto Nacional de Enfermedades Infecciosas) 'Dr. C. G. Malbrán,' ANLIS (Administración Nacional de Laboratorios e Institutos de Salud) Ciudad Autónoma de Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Revista Argentina de microbiologia [Rev Argent Microbiol] 2020 Jul - Sep; Vol. 52 (3), pp. 183-188. Date of Electronic Publication: 2020 Jan 14.
DOI:	10.1016/j.ram.2019.07.005
Abstrakt:	The aim of this work was to know the frequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes isolated from human infections in Argentina during the period from April 2009 to April 2011. A multicenter study was conducted, in which 372 isolates were obtained from 61 laboratories throughout the country. Of those, 98.8% of the isolates belonged to the C. neoformans species complex and 1.1% to the C. gattii species complex. Genotype VNI (MATα) was the most frequently isolated (n=326, 87.6%), followed by VNII (MATα) (n=22, 5.9%), the recently described VNII-VNIV (aADα) hybrid (n=14, 3.8%), VNIV (MATα) (n=4, 1.1%), VNIII (αADa) hybrid (n=1, 0.3%), and VNIII (αADα) hybrid (n=1, 0.3%). The Argentine Central region showed the greatest number of cases and genotype diversity. Interestingly, a relative high frequency was observed in genotype VNII (MATα) in the Cuyo, Northeast and Northwest regions and, also in VNII-VNIV (aADα) hybrids in the Northwest region. C. gattii species complex was isolated at a low rate; 3 VGI (MATα) and 1 VGII (MATα) isolates were obtained from the Northwest and Central regions. In conclusion, this study shows that genotype frequencies seem to vary among regions in Argentina and reveals a relatively high frequency of rare hybrids in the Northwest region. Further regional clinical and environmental studies may help to elucidate if those variations in frequencies are associated with the existence of regional ecological niches or any other regional factors. (Copyright © 2019 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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