Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria.

Autor:	Araújo ACJ; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Freitas PR; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Rodrigues Dos Santos Barbosa C; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Muniz DF; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Esmeraldo Rocha J; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Neto JBA; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., C da Silva MM; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Moura TF; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Pereira RLS; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Ribeiro-Filho J; Gonçalo Moniz Institute, Fundação Oswaldo Cruz (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil., Silva LED; Setor Litoral, Federal University of Paraná, Curitiba 80060-000, Brazil., Amaral WD; Setor Litoral, Federal University of Paraná, Curitiba 80060-000, Brazil., Deschamps C; Setor Litoral, Federal University of Paraná, Curitiba 80060-000, Brazil., Tintino SR; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil., Iriti M; Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy., Vitalini S; Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy., Coutinho HDM; Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Jazyk:	angličtina
Zdroj:	Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2020 Jan 14; Vol. 9 (1). Date of Electronic Publication: 2020 Jan 14.
DOI:	10.3390/antibiotics9010027
Abstrakt:	This study is a pioneer in reporting the antibacterial properties of the species Croton ceanothifolius Baill. The genus Croton belongs to the family Euphorbiaceae composed of numerous species with documented biological activities. However, the pharmacological properties of C. ceanothifolius remain poorly understood. The leaves of this plant were submitted to hydrodistillation for essential oil (CcEO) extraction and the phytochemical characterization of the oil was performed by GC/MS. The minimum inhibitory concentration of the CcEO was determined for the evaluation of antibacterial activity against multiresistant strains of Staphylococcus aureus , Pseudomonas aeruginosa, and Escherichia coli . The antibiotic-modulating activity of the oil, in combination with antibiotics, was also evaluated. The combination of the CcEO with penicillin, norfloxacin, and gentamicin presented a synergistic effect. This effect was more significant for the association with antibiotics of the quinolone and aminoglycoside classes against Escherichia coli . The association of oil with gentamicin showed better results with regard to the Gram-positive strain. The association of the oil with norfloxacin against P. aeruginosa also showed synergism, but the association with penicillin did not change the effect of this antibiotic. Thus, it is concluded that C. ceanothifolius essential oil selectively potentiates the action of antibiotics against multiresistant strains. Competing Interests: The authors declare no conflicts of interest.
Databáze:	MEDLINE
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