| Autor: |
Yousefi A, Fard RS, Eden UT, Brown EN |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2019 Jul; Vol. 2019, pp. 5794-5798. |
| DOI: |
10.1109/EMBC.2019.8856634 |
| Abstrakt: |
Characterizing coordinated brain dynamics present in high-density neural recordings is critical for understanding the neurophysiology of healthy and pathological brain states and to develop principled strategies for therapeutic interventions. In this research, we propose a new modeling framework called State Space Global Coherence (SSGC), which allows us to estimate neural synchrony across distributed brain activity with fine temporal resolution. In this modeling framework, the cross-spectral matrix of neural activity at a specific frequency is defined as a function of a dynamical state variable representing a measure of Global Coherence (GC); we then combine filter-smoother and Expectation-Maximization (EM) algorithms to estimate GC and the model parameters. We demonstrate a SSGC analysis in a 64-channel EEG recording of a human subject under general anesthesia and compare the modeling result with empirical measures of GC. We show that SSGC not only attains a finer time resolution but also provides more accurate estimation of GC. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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