A method to assess lifetime dietary risk: Example of cadmium exposure.

Autor: Pruvost-Couvreur M; Laboratoire d'Etude des Résidus et Contaminants dans les Aliments - Oniris, Route de Gachet, Site de la Chantrerie, CS 50707, 44307, NANTES Cedex 3, France; Risk Assessment Department - French Agency for Food, Environmental and Occupational Health and Safety, 14 Rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Le Bizec B; Laboratoire d'Etude des Résidus et Contaminants dans les Aliments - Oniris, Route de Gachet, Site de la Chantrerie, CS 50707, 44307, NANTES Cedex 3, France., Béchaux C; Risk Assessment Department - French Agency for Food, Environmental and Occupational Health and Safety, 14 Rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Rivière G; Risk Assessment Department - French Agency for Food, Environmental and Occupational Health and Safety, 14 Rue Pierre et Marie Curie, 94700 Maisons-Alfort, France. Electronic address: gilles.riviere@anses.fr.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Mar; Vol. 137, pp. 111130. Date of Electronic Publication: 2020 Jan 13.
DOI: 10.1016/j.fct.2020.111130
Abstrakt: Usually health risk related to food contaminants is assessed based on consumption data collected on a few days. Consequently, this approach considers neither the evolution of exposures over time nor the potential accumulation of the substance. The aim of the present study was to develop a method to assess lifetime dietary risk due to cadmium exposure. Three methods were compared, respectively based on age, dietary pattern and sociodemographic characteristics. Additionally, exposure trajectories were converted into cadmium body burden trajectories using a PBTK-TD model ultimately predicting the occurrence of renal effects. It was shown that dietary exposures to cadmium, as well as exceedances of health based guidance values, greatly vary with age and individual profiles. The developed methods allowed identifying parameters affecting dietary exposure to cadmium and distinguishing at-risk subpopulations. Furthermore, this study demonstrated that it is necessary to consider individual changes through life and kinetic of the substance to assess risk properly.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: