Cytological Diagnosis of Rosai-Dorfman Disease: A Study of Twelve Cases with Emphasis on Diagnostic Challenges.

Autor: Rajyalakshmi R; Department of Pathology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India., Akhtar M; Department of Pathology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India., Swathi Y; Department of Pathology, Crest Labs, Vijayawada, Andhra Pradesh, India., Chakravarthi R; Department of Pathology, Cpath labs, Hyderabad, Telangana, India., Bhaskara Reddy J; Department of Pediatric Surgery, Rangaraya Medical College, Kakinada, Andhra Pradesh, India., Beulah Priscilla M; Department of Pathology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
Jazyk: angličtina
Zdroj: Journal of cytology [J Cytol] 2020 Jan-Mar; Vol. 37 (1), pp. 46-52. Date of Electronic Publication: 2019 Dec 23.
DOI: 10.4103/JOC.JOC_4_19
Abstrakt: Context: Rosai-Dorfman disease, also known as Sinus histiocytosis with massive lymphadenopathy, is a benign proliferative disorder of histiocytes. It typically affects lymph nodes; however, extranodal disease is being increasingly reported. The latter entity poses exceptional diagnostic challenge clinico-radiologically by forming mass lesions. Fine needle aspiration cytology (FNAC) is the investigation of choice to avoid unnecessary surgery as the majority are self-limiting.
Aims: The objective is to assess the utility of FNAC in the diagnosis of Rosai-Dorfman disease and to highlight the diagnostic difficulties.
Material and Methods: The cytology features of 12 cases of Rosai-Dorfman disease were analyzed and correlated with histopathology and immunohistochemistry.
Results: The present study included six nodal and six extranodal Rosai-Dorfman disease. The cytology smears showed a variable number of large histiocytes exhibiting characteristic emperipolesis. Ten cases diagnosed as Rosai-Dorfman disease on cytology were confirmed on histopathology. The presence of granulomas, atypical histiocytes, insignificant emperipolesis, and eosinophil infiltration were the challenges we faced.
Conclusions: FNAC, a simple and cost-effective method with its unique cytology features is the first line of investigation in the diagnosis of Rosai-Dorfman disease.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2019 Journal of Cytology.)
Databáze: MEDLINE
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