| Autor: |
Shadrina DV; Cardioplant Company, Federal Center of Cardiovascular Surgery, Penza, Russia. shadrina.dv@yandex.ru., Venediktov AA; Cardioplant Company, Federal Center of Cardiovascular Surgery, Penza, Russia., Evdokimov SV; MedInzh Research-and-Production Company, Penza, Russia., Vaskovskii VA; A. V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia., Artyukhina EA; A. V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia., Revishvili AS; A. V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russia., Durmanov SS; Federal Center of Cardiovascular Surgery, Penza, Russia., Bazylev VV; Federal Center of Cardiovascular Surgery, Penza, Russia. |
| Abstrakt: |
We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of porcine small intestine), an acellular extracellular collagen matrix was obtained. The biocompatibility of the material was tested in vitro using stem cell cultures. The biomaterial for fabrication of the envelope is not cytotoxic, biocompatible, and represents a suitable substrate for attachment, growth, and reproduction of stem cells. The biological effect of the material was studied in vivo on the model of heterotopic implantation in small laboratory animals. The biomaterial did not induce inflammation and tissue reaction and was completely transformed into healthy vascularized tissue without scars in 90 days after implantation. |
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