A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size.

Autor:	Arimura H; Department of Diabetes and Endocrine Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima, Japan.; Pituitary Disorders Center, Kagoshima University Hospital, Kagoshima, Kagoshima, Japan., Askoro R; Faculty of Medicine, Diponegoro University, Semarang, Indonesia.; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan., Fujio S; Pituitary Disorders Center, Kagoshima University Hospital, Kagoshima, Kagoshima, Japan.; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan., Ummah FC; Faculty of Medicine, Diponegoro University, Semarang, Indonesia.; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan., Takajo T; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan., Nagano Y; Pituitary Disorders Center, Kagoshima University Hospital, Kagoshima, Kagoshima, Japan.; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan., Nishio Y; Department of Diabetes and Endocrine Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima, Japan., Arita K; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshia, Japan.
Jazyk:	angličtina
Zdroj:	NMC case report journal [NMC Case Rep J] 2019 Dec 18; Vol. 7 (1), pp. 17-21. Date of Electronic Publication: 2019 Dec 18 (Print Publication: 2020).
DOI:	10.2176/nmccrj.cr.2018-0323
Abstrakt:	We treated an extremely rare thyroid-stimulating hormone (TSH)-producing pituitary adenoma in a 63-year-old woman with severe hypothyroidism due to autoimmune thyroiditis. She was presented with dizziness and fatigue. The blood level of TSH, prolactin, and fT4 was 288.2 μIU/mL, 72.9 ng/mL, and 0.24 ng/dL, respectively. Magnetic resonance imaging demonstrated a large pituitary tumor, 31 mm in height, and a normal pituitary gland. Preoperative thyroxine replacement reduced the TSH level to 2.05 μIU/mL and produced a significant reduction in the tumor volume. Histopathologically, the surgically removed tumor was a TSH-producing pituitary adenoma. Competing Interests: Conflicts of Interest Disclosure The authors state that they have no conflict of interest. (© 2020 The Japan Neurosurgical Society.)
Databáze:	MEDLINE
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