Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.

Autor: Lal KG; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Kim D; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Costanzo MC; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Creegan M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Leeansyah E; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore., Dias J; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Paquin-Proulx D; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Eller LA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Schuetz A; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.; Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Phuang-Ngern Y; Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Krebs SJ; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Slike BM; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Kibuuka H; Makerere University Walter Reed Project, Kampala, Uganda., Maganga L; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Nitayaphan S; Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Kosgei J; Kenya Medical Research Institute/U.S. Army Medical Research Directorate-Africa/Kenya, Kericho, Kenya., Sacdalan C; SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Ananworanich J; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.; SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Bolton DL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Michael NL; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Shacklett BL; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA., Robb ML; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Eller MA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Sandberg JK; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. johan.sandberg@ki.se.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Jan 14; Vol. 11 (1), pp. 272. Date of Electronic Publication: 2020 Jan 14.
DOI: 10.1038/s41467-019-13975-9
Abstrakt: Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.
Databáze: MEDLINE