| Autor: |
Sviridova AA; Pirogov Russian National Research Medical University, Moscow, Russia; Federal Center of Cerebrovascular Pathology and Stroke, Moscow, Russia., Kabaeva AR; Pirogov Russian National Research Medical University, Moscow, Russia., Rogovskii VS; Pirogov Russian National Research Medical University, Moscow, Russia., Kozhieva MK; Pirogov Russian National Research Medical University, Moscow, Russia., Melnikov MV; Pirogov Russian National Research Medical University, Moscow, Russia; Federal Center of Cerebrovascular Pathology and Stroke, Moscow, Russia; Institute of Immunology, Laboratory of Clinical Immunology, Moscow, Russia., Boyko AN; Pirogov Russian National Research Medical University, Moscow, Russia; Federal Center of Cerebrovascular Pathology and Stroke, Moscow, Russia. |
| Abstrakt: |
Biogenic amines are key mediators of neuroimmune interaction and may influence on multiple sclerosis (MS) pathogenesis and MS course. At the same time, the role of biogenic amines in immunoregulation of early stages of demyelination, in particular clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) is still unclear. This literature review addresses a role of norepinephrine in the regulation of neuroimmune interactions in the early stages of the demyelination. Neuropsychological disorders, immunological characteristics, gut-brain axis as well as the role of norepinephrine in these interactions in patients with CIS, RIS and early MS are discussed. |
