Fibrous dysplasia as a possible false-positive finding in 68 Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer.

Autor: Ribeiro AMB; Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, Brazil., Lima ENP; Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, Brazil., Rocha MM; Department of Urology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: World journal of nuclear medicine [World J Nucl Med] 2019 Dec 18; Vol. 18 (4), pp. 409-412. Date of Electronic Publication: 2019 Dec 18 (Print Publication: 2019).
DOI: 10.4103/wjnm.WJNM_111_18
Abstrakt: Positron emission tomography/computed tomography (PET/CT) using 68 Ga-labeled prostate-specific membrane antigen ( 68 Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen. 68 Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68 Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2019 World Journal of Nuclear Medicine.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje