Temporally restricted dopaminergic control of reward-conditioned movements.

Autor: Lee K; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Claar LD; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.; Allen Institute for Brain Science, Seattle, WA, USA., Hachisuka A; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Bakhurin KI; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA., Nguyen J; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Trott JM; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA., Gill JL; Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, CA, USA., Masmanidis SC; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA. smasmanidis@ucla.edu.; California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA. smasmanidis@ucla.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2020 Feb; Vol. 23 (2), pp. 209-216. Date of Electronic Publication: 2020 Jan 13.
DOI: 10.1038/s41593-019-0567-0
Abstrakt: Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licking before reward delivery. Inhibiting both ventral tegmental area and substantia nigra pars compacta DA neurons in the post-reward period had a significantly greater behavioral effect than inhibition in the pre-reward period of the task. Furthermore, the contribution of DA neurons to behavior decreased linearly as a function of elapsed time after reward. Together, the results indicate a temporally restricted role of DA neurons primarily related to reinforcing stimulus-reward associations and suggest that directly generating movements is a comparatively less important function.
Databáze: MEDLINE
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