Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions.

Autor:	Lemaster JE; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Jeevarathinam AS; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Kumar A; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Chandrasekar B; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Chen F; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Radiology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Jokerst JV; Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.; Department of Radiology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Jazyk:	angličtina
Zdroj:	ACS applied bio materials [ACS Appl Bio Mater] 2019 Oct 21; Vol. 2 (10), pp. 4667-4674. Date of Electronic Publication: 2019 Sep 26.
DOI:	10.1021/acsabm.9b00747
Abstrakt:	Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficult-especially for materials below 1000 nm. In this paper we describe the synthesis of ultrasmall synthetic nanoparticles with size of 9.4-31.4 nm in weakly acidic and neutral conditions via UV-irradiation. Size control of these particles was possible by varying the pH from 6.4-10.0. We then used UV-vis, FTIR, and nuclear magnetic resonance to investigate the mechanism of UV-induced polymerization. The data show that reactive oxygen species from UV irradiation oxidizes intermediates of the reaction and accelerates the formation of these synthetic melanin structures. Competing Interests: The authors declare no competing financial interest.
Databáze:	MEDLINE
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