Effects of ivermectin treatment during prepubertal and pubertal period on sexual parameters and sexual behavior in adulthood in rats.

Autor: Moreira N; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; Graduate Program of Enviromental and Experimental Pathology and Graduate Program of Dentistry, Paulista University, São Paulo, SP, Brazil. Electronic address: nmoreira@usp.br., Vicente FL; Student of Health Science Institute, Presbiterian Mackenzie University, São Paulo, SP, Brazil., Sandini TM; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK, Canada., Martinelli ECL; Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, SP, Brazil., Navas-Suárez PE; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil., Reis-Silva TM; Graduate Program of Enviromental and Experimental Pathology and Graduate Program of Dentistry, Paulista University, São Paulo, SP, Brazil., Spinosa HS; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2020 Apr; Vol. 129, pp. 21-27. Date of Electronic Publication: 2019 Dec 16.
DOI: 10.1016/j.rvsc.2019.12.013
Abstrakt: Pediculosis is a parasitic disease that is considered a serious global public health problem. It is caused by the ectoparasite that is popularly known as lice, mainly affecting children in early childhood. The most commonly used treatment to combat this parasitosis is the macrocyclic lactone ivermectin (IVM). However, the use of IVM is contraindicated in children who are younger than 5 years old or who weigh <15 kg because some types of drugs that are used during certain periods of brain maturation can lead to behavioral disorders. The present study evaluated the effects of IVM treatment during the prepubertal and pubertal period on sexual behavior in adulthood in male rats. Genital grooming, preputial separation, sexual behavior, sexual motivation, relative organ weight, the gonadosomatic index, and histopathology were evaluated. Oral dose of 0.2 mg/kg (therapeutic dose) of a commercial IVM formulation was administered. IVM affected genital grooming but did not influence preputial separation in prepubertal rats. Prepubertal IVM administration did not impair sexual behavior in adult rats, with the exception of the time of residence with female rats in the sexual motivation test. It did not affect relative organ weights, with the exception of the relative weight of the full seminal vesicle. It did not alter the gonadosomatic index, and no histopathological alterations were observed in different organs. These results indicate that administration of a therapeutic dose of IVM during the prepubertal and pubertal period does not alter parameters of sexual development or sexual behavior in adult male rats.
Competing Interests: Declaration of Competing Interest All authors declare that there are no conflicts of interest.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: