Spatially resolved proteomics in osteoarthritis: State of the art and new perspectives.

Autor: Eveque-Mourroux MR; The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, the Netherlands., Rocha B; Proteomics Group-ProteoRed/ISCIII, Grupo de Investigación de Reumatología (GIR), INIBIC - Hospital Universitario de A Coruña, A Coruña, Spain., Barré FPY; The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, the Netherlands., Heeren RMA; The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, the Netherlands., Cillero-Pastor B; The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, the Netherlands. Electronic address: b.cilleropastor@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: Journal of proteomics [J Proteomics] 2020 Mar 20; Vol. 215, pp. 103637. Date of Electronic Publication: 2020 Jan 09.
DOI: 10.1016/j.jprot.2020.103637
Abstrakt: Osteoarthritis (OA) is one of the most common diseases worldwide caused by chronic degeneration of the joints. Its high prevalence and the involvement of several tissues define OA as a highly heterogeneous disease. New biological markers to evaluate the progression of the pathology and improve its prognosis are needed. Among all the different -omic strategies applied to OA, solution phase bottom-up proteomics has made an extensive contribution to the field of biomarker research. However, new technologies for protein analysis should be considered for a better understanding of the disease. This review focuses on complementary proteomic methodologies and new technologies for translational research of OA and other rheumatic pathologies, especially mass spectrometry imaging and protein imaging methods not applied by the OA community yet.
Competing Interests: Declaration of Competing Interest There are no conflicts to declare.
(Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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