The Association Between Secondhand Smoke Exposure and Survival for Patients With Heart Failure.

Autor: Psotka MA; Inova Heart and Vascular Institute, Falls Church, Virginia., Rushakoff J; Division of Cardiology, Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California., Glantz SA; Division of Cardiology, Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California., De Marco T; Division of Cardiology, Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California., Fleischmann KE; Division of Cardiology, Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California. Electronic address: Kirsten.Fleischmann@ucsf.edu.
Jazyk: angličtina
Zdroj: Journal of cardiac failure [J Card Fail] 2020 Sep; Vol. 26 (9), pp. 745-750. Date of Electronic Publication: 2020 Jan 09.
DOI: 10.1016/j.cardfail.2019.12.008
Abstrakt: Background: The effect of secondhand tobacco smoke (SHS) exposure on patients with heart failure (HF) is uncertain. We investigated the association of mortality with SHS exposure for patients with HF.
Methods: Nonsmokers with clinical HF were enrolled from 2003 to 2008 in a single-center longitudinal cohort study. The effect of SHS exposure determined by high-sensitivity urinary cotinine on mortality was estimated by multivariable proportional hazards modeling.
Results: Mortality was assessed after median 4.3 years. Of 202 patients, enrollment urinary cotinine levels were below the limit of detection for 106 (52%) considered unexposed to SHS. The median detectable cotinine was 0.47 ng/mL (interquartile range: [0.28, 1.28]). Participants were 41% female, 65 ± 17 years old, and 57% white race. Elevated cotinine was associated with increased mortality after multivariate adjustment: hazard ratio (HR) per 1 ng/mL increase in urinary cotinine: 1.15, 95% confidence interval (CI): 1.08-1.23, P < .001. Higher age (HR per 5-year increase: 1.32, 95% CI: 1.22-1.43, P < .001), male sex (HR vs female: 1.52, 95% CI: 1.02-2.28, P = .040), and New York Heart Association class (HR for class III vs I: 2.91, 95% CI: 1.71-4.99, P < .001) were also associated with mortality.
Conclusions: SHS exposure is associated with a dose-dependent increase in mortality for patients with HF.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: