Comparative clinical study of the efficacy of intralesional MMR vaccine vs intralesional vitamin D injection in treatment of warts.

Autor: Shaldoum DR; MBBCh. Faculty of medicine, Tanta University., Hassan GFR; Dermatology and Venereology, Faculty of medicine, Tanta University, Tanta, Egypt., El Maadawy EH; Dermatology and Venereology, Faculty of medicine, Tanta University, Tanta, Egypt., El-Maghraby GM; Pharmaceutical Technology, Faculty of pharmacy, Tanta University, Tanta, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2020 Aug; Vol. 19 (8), pp. 2033-2040. Date of Electronic Publication: 2020 Jan 11.
DOI: 10.1111/jocd.13272
Abstrakt: Background: Many therapeutic modalities were reported for the treatment of warts; however, no single treatment is completely effective.
Objective: To evaluate the efficacy of intralesional injection of MMR vaccine vs vitamin D in treatment of warts.
Patients and Methods: A total of 60 patients were included in the study divided into two groups. Group A received intralesional MMR vaccine into largest wart, and group B received intralesional vitamin D 3 into each lesion with maximum of five warts treated in one session. A maximum of six sessions was done every 3 weeks in both groups. Follow-up was done for 6 months for any recurrence.
Results: In group A: complete response in 80%, partial response in 6.67%, minimal response in 6.67%, and no response in 6.67% of patients. About 60% of patients with multiple warts showed complete clearance of distant untreated warts. In group B: complete response in 66.7%, partial response in 6.67%, minimal response in 20%, and no response in 6.67% of patients. There was no significant difference between both groups. No recurrence was observed in both groups in the follow-up period.
Conclusions: Immunotherapy by both intralesional MMR vaccine and vitamin D 3 is simple, well-tolerated, effective, and cost-benefit modalities for the treatment of warts.
(© 2020 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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