The role of Lactobacillus species in the control of Candida via biotrophic interactions.
| Autor: | Zangl I; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Applied Genetics and Cell Biology (DAGZ), Tulln, Austria., Pap IJ; University Hospital of St. Pölten, Institute for Hygiene and Microbiology, St Pölten, Austria., Aspöck C; University Hospital of St. Pölten, Institute for Hygiene and Microbiology, St Pölten, Austria., Schüller C; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Applied Genetics and Cell Biology (DAGZ), Tulln, Austria.; Bioactive Microbial Metabolites (BiMM), BOKU, Tulln, Austria. |
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| Jazyk: | angličtina |
| Zdroj: | Microbial cell (Graz, Austria) [Microb Cell] 2019 Nov 25; Vol. 7 (1), pp. 1-14. Date of Electronic Publication: 2019 Nov 25. |
| DOI: | 10.15698/mic2020.01.702 |
| Abstrakt: | Microbial communities have an important role in health and disease. Candida spp. are ubiquitous commensals and sometimes opportunistic fungal pathogens of humans, colonizing mucosal surfaces of the genital, urinary, respiratory and gastrointestinal tracts and the oral cavity. They mainly cause local mucosal infections in immune competent individuals. However, in the case of an ineffective immune defense, Candida infections may become a serious threat. Lactobacillus spp. are part of the human microbiome and are natural competitors of Candida in the vaginal environment. Lactic acid, low pH and other secreted metabolites are environmental signals sensed by fungal species present in the microbiome. This review briefly discusses the ternary interaction between host, Lactobacillus species and Candida with regard to fungal infections and the potential antifungal and fungistatic effect of Lactobacillus species. Our understanding of these interactions is incomplete due to the variability of the involved species and isolates and the complexity of the human host. Competing Interests: Conflict of interest: The authors declare that there is no conflict of interest. |
| Databáze: | MEDLINE |
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