Emerging Functions of Human IFIT Proteins in Cancer.

Autor:	Pidugu VK; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Pidugu HB; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wu MM; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Liu CJ; Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan., Lee TC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2019 Dec 19; Vol. 6, pp. 148. Date of Electronic Publication: 2019 Dec 19 (Print Publication: 2019).
DOI:	10.3389/fmolb.2019.00148
Abstrakt:	Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes named IFIT1, IFIT2, IFIT3 , and IFIT5 . The expression of IFIT genes is very low in most cell types, whereas their expression is greatly enhanced by interferon treatment, viral infection, and pathogen-associated molecular patterns (PAMPs). The proteins encoded by IFIT genes have multiple tetratricopeptide repeat (TPR) motifs. IFIT proteins do not have any known enzymatic roles. However, they execute a variety of cellular functions by mediating protein-protein interactions and forming multiprotein complexes with cellular and viral proteins through their multiple TPR motifs. The versatile tertiary structure of TPR motifs in IFIT proteins enables them to be involved in distinct biological functions, including host innate immunity, antiviral immune response, virus-induced translation initiation, replication, double-stranded RNA signaling, and PAMP recognition. The current understanding of the IFIT proteins and their role in cellular signaling mechanisms is limited to the antiviral immune response and innate immunity. However, recent studies on IFIT protein functions and their involvement in various molecular signaling mechanisms have implicated them in cancer progression and metastasis. In this article, we focused on critical molecular, biological and oncogenic functions of human IFIT proteins by reviewing their prognostic significance in health and cancer. Research suggests that IFIT proteins could be novel therapeutic targets for cancer therapy. (Copyright © 2019 Pidugu, Pidugu, Wu, Liu and Lee.)
Databáze:	MEDLINE
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