| Autor: |
Abbasi H; Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Dastgheib SA; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Hadadan A; Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Karimi-Zarchi M; Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.; Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Javaheri A; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Meibodi B; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Zanbagh L; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran., Tabatabaei RS; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Neamatzadeh H; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. |
| Abstrakt: |
Background: Several case-control studies have been performed to investigate the association between 894 G > T polymorphism in endothelial nitric oxide synthase (eNOS) gene and susceptibility to preeclampsia. However, the results were inconsistent and inconclusive. Therefore, we conducted this meta-analysis to investigate the association. Methods : All studies published up to September 30, 2019 were identified by searching electronic databases such as PubMed, EMBASE, CNKI, and WANFANG. Results : A total of 35 case- control studies with 4,254 cases and 5,801 controls were selected. There was a significant association between the eNOS 894 G > T and preeclampsia risk. When stratified by ethnicity, an increased risk of preeclampsia was found in Caucasian and Mixed populations, but not in Asians or Africans. Conclusion : Based on our meta-analysis, the eNOS 894 G > T polymorphism was associated with an increased risk of preeclampsia, especially among Caucasian and Mixed populations. |
