Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat.

Autor: Mohammed HS; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., Hosny EN; Medical Physiology Department, National Research Centre, Giza, Egypt. Electronic address: emannasr_30@yahoo.com., Khadrawy YA; Medical Physiology Department, National Research Centre, Giza, Egypt., Magdy M; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., Attia YS; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., Sayed OA; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., AbdElaal M; Physics Department, Faculty of Science, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 May 01; Vol. 1866 (5), pp. 165665. Date of Electronic Publication: 2020 Jan 07.
DOI: 10.1016/j.bbadis.2020.165665
Abstrakt: The present study designed to investigate the protective effect of curcumin nanoparticles (CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; control, rats treated daily with CUR-NPs (50 mg/kg) for 14 days, rats treated with an acute dose of doxorubicin (20 mg/kg) and rats treated daily with CUR-NPs for 14 days injected with doxorubicin on the 10th day. After electrocardiogram (ECG) recording from rats at different groups, rat decapitation was carried out and the heart of each rat was excised out to measure the oxidative stress parameters; lipid peroxidation (MDA), nitric oxide (NO) and reduced glutathione (GSH) and the activities of Na,K,ATPase and acetylcholinesterase (AchE). In addition, the levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) were determined in the cardiac tissues. Lactate dehydrogenase (LDH) activity was measured in the serum. The ECG recordings indicated that daily pretreatment with CUR- NPs has prevented the tachycardia (i.e. increase in heart rate) and ameliorated the changes in ST wave and QRS complex induced by doxorubicin. In addition, CUR-NPs prevented doxorubicin induced significant increase in MDA, NO, DA, AchE and LDH and doxorubicin induced significant decrease in GSH, NE, 5-HT and Na,K,ATPase. According to the present findings, it could be concluded that CUR-NPs have a protective effect against cardiotoxicity induced by doxorubicin. This may shed more light on the importance of CUR-NPs pretreatment before the application of doxorubicin therapy.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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