| Autor: |
de Moura VM; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Ames FQ; Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Corrêa JGS; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Peixoto MA; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Amorim AMA; Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil., Pomini AM; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., de Carvalho JE; Centro Pluridisciplinar de Pesquisa Químicas, Biológicas e Agrícolas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Ruiz ALTG; Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil., Bersani-Amado CA; Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, Paraná, Brazil., Santin SMO; Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. |
| Abstrakt: |
Palicourea species has been used in folk medicine in the treatment of some diseases including cancer and inflammatory disorders. This work aimed to evaluate the in vitro antiproliferative and in vivo topical anti-inflammatory activities of the methanolic extract, fractions and two major alkaloids isolated from Palicourea minutiflora . Methanolic extract, non-alkaloidal and alkaloidal fractions exhibited strong growth inhibition for ovarian cell lines (OVCAR-3, GI 50 = 3.8 at 16.3 µg mL -1 ) and the vincosamide alkaloid revealed selective effect on the growth of glioma cell lines (U251, GI 50 = 33.0 µg mL -1 ) compared with doxorubicin (DOX, GI 50 = 0.42 and 0.025 µg mL -1 , respectively) anticancer drug. Methanolic extract, fractions and strictosidinic acid showed significant inhibitory effect with 62.7% at 77.5% (p < 0.05) to ear edema induced by croton oil and 81% at 100% (p < 0.05) to myeloperoxidase assay compared with indomethacin (positive control) 68.4% and 91.3% (p < 0.05), respectively. |
