| Autor: |
Zhong SC; Department of Pathology and Clinical Laboratory, 96601 Army Hospital of People's Liberation Army, Huangshan, China., Ao XJ; Department of Medical Oncology, 96601 Army Hospital of People's Liberation Army, Huangshan, China., Yu SH; Department of Pathology and Clinical Laboratory, 96601 Army Hospital of People's Liberation Army, Huangshan, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2020 Mar; Vol. 25 (2), pp. 157-163. Date of Electronic Publication: 2020 Jan 21. |
| DOI: |
10.1080/1354750X.2020.1714735 |
| Abstrakt: |
Background: Previous studies have demonstrated the diagnostic value of glucose transporter 1 (GLUT-1) to distinguish malignant mesothelioma (MM) from reactive mesothelial cells (RMC), but the results are inconsistent. The purpose of this meta-analysis is to investigate the diagnostic accuracy of GLUT-1 in distinguishing MM from RMC. Methods: A systematical search was conducted until May 2019 in PubMed, Medline, Embase and the Cochrane Library. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess the quality of the eligible studies. The Stata15 and Review Manager5.3 software programmes were used to perform the meta-analysis. Results: A total of 24 studies, including 969 MM patients and 1080 RMC individuals were explored in the meta-analysis. The summary assessments revealed that the pooled sensitivity was 0.73 (95% CI, 0.62-0.81) and the pooled specificity was 0.95 (95% CI, 0.91-0.98). The area under the summary ROC curve (AUC) was 0.93 (95% CI: 0.91-0.95). Conclusions: GLUT-1 is highly accurate to distinguish MM from RMC. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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