Protective role of lycopene against metabolic disorders induced by chronic bisphenol A exposure in rats.

Autor: Elgawish RA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., El-Beltagy MA; Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., El-Sayed RM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, El-, Arish, Egypt., Gaber AA; Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., Abdelrazek HMA; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. vet_rose2005@yahoo.com.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Mar; Vol. 27 (9), pp. 9192-9201. Date of Electronic Publication: 2020 Jan 08.
DOI: 10.1007/s11356-019-07509-5
Abstrakt: This study was conducted to elucidate the ameliorative potential of lycopene (LYC) against the metabolic toxicity induced by bisphenol A (BPA) in rats. Male rats (n = 28) were divided into 4 equal groups: control group, LYC group was given lycopene (10 mg/kg BW), BPA group was given 10 mg/kg BW of BPA, and the last group was administered BPA and LYC at 10 mg/kg via gavage for 90 consecutive days. Body weight (BW) gain, lipid profile, and total antioxidant capacity (TAC) were assessed. Oral glucose tolerance test (OGTT), homeostasis model assessment-estimated insulin resistance (HOMA-IR), thyroid hormones, interleukin-1 beta (IL-1β), leptin, and resistin were assayed. Moreover, immunohistochemistry of TNF-α was performed in adipose tissue. BPA-treated rats showed significant reduction in BW gain and deteriorations in lipid profile, TAC, OGTT, and thyroid hormones as well as significant increases in HOMA-IR, IL-1β, leptin, and resistin. While, improvement of metabolic parameters was observed when LYC was administrated with BPA. Intense TNF-α immunostaining was detected in the fat of BPA-treated rats but the intensity decreased when LYC was administrated with BPA. In conclusion, LYC ameliorated the adverse effects of BPA on metabolism through its antioxidant potential and its reduction of TNF-α expression in adipose tissue.
Databáze: MEDLINE
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