Fluorescent glycoconjugates and their applications.

Autor: Thomas B; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire de Chimie Organique 2-Glycochimie, UMR 5246, CNRS and Université Claude Bernard Lyon 1, Université de Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France. sebastien.vidal@univ-lyon1.fr., Yan KC; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn xphe@ecust.edu.cn., Hu XL; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn xphe@ecust.edu.cn., Donnier-Maréchal M; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire de Chimie Organique 2-Glycochimie, UMR 5246, CNRS and Université Claude Bernard Lyon 1, Université de Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France. sebastien.vidal@univ-lyon1.fr., Chen GR; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn xphe@ecust.edu.cn., He XP; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. mrs_guorongchen@ecust.edu.cn xphe@ecust.edu.cn., Vidal S; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire de Chimie Organique 2-Glycochimie, UMR 5246, CNRS and Université Claude Bernard Lyon 1, Université de Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France. sebastien.vidal@univ-lyon1.fr.
Jazyk: angličtina
Zdroj: Chemical Society reviews [Chem Soc Rev] 2020 Jan 21; Vol. 49 (2), pp. 593-641. Date of Electronic Publication: 2020 Jan 09.
DOI: 10.1039/c8cs00118a
Abstrakt: Glycoconjugates and their applications as lectin ligands in biology have been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The present review will focus on multivalent glycoconjugates displaying an additional capability such as fluorescence properties not only for applications toward imaging of cancer cells and detection of proteins or pathogens but also for drug delivery systems toward targeted cancer therapy. This review is a collection of research articles discussed in the context of the structural features of fluorescent glycoconjugates organized according to their fluorescent core scaffold and with their representative applications.
Databáze: MEDLINE
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