Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations.

Autor: Kessler HH; Research Unit Molecular Diagnostics, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz, Austria., Stelzl E; Research Unit Molecular Diagnostics, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz, Austria., Blažič A; Research Unit Molecular Diagnostics, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz, Austria., Mehta SR; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, USA.; Department of Medicine, San Diego VA Medical Center, San Diego, California, USA., Benezeder AS; Research Unit Molecular Diagnostics, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz, Austria., Genger-Hackl C; Department of Gastroenterology and Infectious Diseases, Academic Hospital Graz II, Graz, Austria., Santner BI; Research Unit Molecular Diagnostics, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz, Graz, Austria., Chaillon A; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, USA., Hoenigl M; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, USA.; Division of Pulmonology and Section of Infectious Diseases, Medical University of Graz, Graz, Austria.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2019 Dec 18; Vol. 7 (1), pp. ofz535. Date of Electronic Publication: 2019 Dec 18 (Print Publication: 2020).
DOI: 10.1093/ofid/ofz535
Abstrakt: The frequency of clinically relevant transmitted drug resistance mutations (DRMs) against drugs used for 2-drug regimens was 15.6%, but only 2% were not eligible for 1 or more 2-drug regimens. More than 50% of patients harboring any clinically relevant DRMs were found to be part of genetic transmission clusters.
(© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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