Usefulness of Routine Fractional Flow Reserve for Clinical Management of Coronary Artery Disease in Patients With Diabetes.

Autor:	Van Belle E; Département de Cardiologie, Institut Coeur-Poumon, Centre Hospitalier Universitaire de Lille, Lille, France.; Institut national de la santé et de la recherche médicale INSERM U1011, Lille-II-University, Lille, France., Cosenza A; Département de Cardiologie, Institut Coeur-Poumon, Centre Hospitalier Universitaire de Lille, Lille, France.; Institut national de la santé et de la recherche médicale INSERM U1011, Lille-II-University, Lille, France., Baptista SB; Serviço de Cardiologia, Hospital Prof Doutor Fernando da Fonseca, Amadora, Portugal.; University Clinic of Cardiology-Faculty of Medicine at University of Lisbon, Lisbon, Portugal., Vincent F; Département de Cardiologie, Institut Coeur-Poumon, Centre Hospitalier Universitaire de Lille, Lille, France.; Institut national de la santé et de la recherche médicale INSERM U1011, Lille-II-University, Lille, France., Henderson J; Statistical Department, St. Jude Medical Inc, St Paul, Minnesota., Santos L; Serviço de Cardiologie, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal., Ramos R; Serviço de Cardiologia, Hospital Santa Marta-Centro Hospitalar Lisboa Central, Lisboa, Portugal., Pouillot C; Department de Cardiologia, Clinique Sainte Clotilde, Saint Denis de la Réunion, France., Calé R; Serviço de Cardiologia, Hospital Garcia de Orta, Almada, Portugal., Cuisset T; Department de Cardiologie, Centre Hospitalar Universitaire, La Timone, Marseille, France., Jorge E; Serviço de Cardiologia, Centro Hospitalar Universitário, Coimbra, Coimbra, Portugal., Teiger E; Department of Cardiologie, Centre Hospitalar Universitaire Mondor, Créteil, France., Machado C; Serviço de Cardiologia, Hospital Divino Espirito Santo, Ponta Delgada, Portugal., Belle L; Department de Cardiologie, Centre Hospitalier d'Annecy, Annecy, France., Costa M; Serviço de Cardiologia, Hospital Geral dos Covões-Centro Hospitalar Coimbra, Coimbra, Portugal., Barreau D; Department of Cardiologie, Centre Hospitalier Intercommunal Toulon La Seyne sur Mer-Hôpital Sainte Musse, Toulon, France., Oliveira E; Serviço de Cardiologia, Hospital Santa Maria-Centro Hospitalar Lisboa Norte, Lisboa, Portugal., Hanssen M; Department de Cardiologie, Centre Hospitalier Haguenau, Haguenau, France., Costa J; Serviço de Cardiologia, Hospital de Braga, Braga, Portugal., Besnard C; Department of Cardiologie, Hôpital de la Croix-Rousse, Lyon, France., Nunes L; Serviço de Cardiologia, Hospital São Teotónio, Viseu, Portugal., Dallongeville J; Institut Pasteur de Lille, Institut national de la santé et de la recherche médicale INSERM, Lille, France., Sideris G; Department of Cardiologie, Hôpital Lariboisière, Paris, France., Bretelle C; Department of Cardiologie, Centre Hospitalier Valence, Valence, France., Fonseca N; Serviço de Cardiologia, Centro Hospitalar Setúbal, Setúbal, Portugal., Lhoest N; Department of Cardiologie, Hôpital Albert Schweizer, Colmar, France., Guardado J; Serviço de Cardiologia, Hospital Santo André-Centro Hospitalar Leiria-Pombal, Leiria, Portugal., Silva B; Serviço de Cardiologia, Hospital Dr Nélio Mendonça, Funchal, Portugal., Sousa MJ; Serviço de Cardiologia, Hospital Geral Santo António-Centro Hospitalar do Porto, Porto, Portugal., Barnay P; Department of Cardiologie, Centre Hospitalier La Durance, Avignon, France., Silva JC; Serviço de Cardiologia, Centro Hospitalar São João, Porto, Portugal., Leborgne L; Department of Cardiologie, Centre Hospitalier Amiens Sud, Amiens, France., Rodrigues A; Serviço de Cardiologia, Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal., Porouchani S; Département de Cardiologie, Institut Coeur-Poumon, Centre Hospitalier Universitaire de Lille, Lille, France., Seca L; Serviço de Cardiologia, Centro Hospitalar Trás-os-Montes e Alto Douro-Unidade Hospitalar Vila Real, Vila Real, Portugal., Fernandes R; Serviço de Cardiologia, Hospital Espírito Santo, Évora, Portugal., Dupouy P; Department of Cardiologie, Hôpital Privé d'Antony, Antony, France., Raposo L; Serviço de Cardiologia, Hospital de Santa Cruz-Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal.
Jazyk:	angličtina
Zdroj:	JAMA cardiology [JAMA Cardiol] 2020 Mar 01; Vol. 5 (3), pp. 272-281.
DOI:	10.1001/jamacardio.2019.5097
Abstrakt:	Importance: Approximately one-third of patients considered for coronary revascularization have diabetes, which is a major determinant of clinical outcomes, often influencing the choice of the revascularization strategy. The usefulness of fractional flow reserve (FFR) to guide treatment in this population is understudied and has been questioned. Objective: To evaluate the usefulness and rate of major adverse cardiovascular events (MACE) of integrating FFR in management decisions for patients with diabetes who undergo coronary angiography. Design, Setting, and Participants: This cross-sectional study used data from the PRIME-FFR study derived from the merger of the POST-IT study (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease [March 2012-November 2013]) and R3F study (French Study of FFR Integrated Multicenter Registries Implementation of FFR in Routine Practice [October 2008-June 2010]), 2 prospective multicenter registries that shared a common design. A population of all-comers for whom angiography disclosed ambiguous lesions was analyzed for rates, patterns, and outcomes associated with management reclassification, including revascularization deferral, in patients with vs without diabetes. Data analysis was performed from June to August 2018. Main Outcomes and Measures: Death from any cause, myocardial infarction, or unplanned revascularization (MACE) at 1 year. Results: Among 1983 patients (1503 [77%] male; mean [SD] age, 65 [10] years), 701 had diabetes, and FFR was performed for 1.4 lesions per patient (58.2% of lesions in the left anterior descending artery; mean [SD] stenosis, 56% [11%]; mean [SD] FFR, 0.81 [0.01]). Reclassification by FFR was high and similar in patients with and without diabetes (41.2% vs 37.5%, P = .13), but reclassification from medical treatment to revascularization was more frequent in the former (142 of 342 [41.5%] vs 230 of 730 [31.5%], P = .001). There was no statistical difference between the 1-year rates of MACE in reclassified (9.7%) and nonreclassified patients (12.0%) (P = .37). Among patients with diabetes, FFR-based deferral identified patients with a lower risk of MACE at 12 months (25 of 296 [8.4%]) compared with those undergoing revascularization (47 of 257 [13.1%]) (P = .04), and the rate was of the same magnitude of the observed rate among deferred patients without diabetes (7.9%, P = .87). Status of insulin treatment had no association with outcomes. Patients (6.6% of the population) in whom FFR was disregarded had the highest MACE rates regardless of diabetes status. Conclusions and Relevance: Routine integration of FFR for the management of coronary artery disease in patients with diabetes may be associated with a high rate of treatment reclassification. Management strategies guided by FFR, including revascularization deferral, may be useful for patients with diabetes.
Databáze:	MEDLINE
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