| Autor: |
Bardot V; PiLeJe Industrie, Naturopôle Nutrition Santé, Les Tiolans, F-03800 Saint-Bonnet-de-Rochefort, France. m.dubourdeaux@pileje.com., Escalon A, Ripoche I, Denis S, Alric M, Chalancon S, Chalard P, Cotte C, Berthomier L, Leremboure M, Dubourdeaux M |
| Jazyk: |
angličtina |
| Zdroj: |
Food & function [Food Funct] 2020 Jan 29; Vol. 11 (1), pp. 722-729. |
| DOI: |
10.1039/c9fo01144g |
| Abstrakt: |
The objective of this study was to evaluate the benefits of a new extraction process, the ipowder® technology, applied to Melissa officinalis L. Compared to M. officinalis ground dry leaves, the ipowder® had a similar phytochemical fingerprint but contained twice the concentration of rosmarinic acid (by HPTLC and HPLC) and had a two-fold greater antioxidant activity (DPPH* method). In vitro digestion experiments (TIM-1 model) showed better availability of rosmarinic acid for intestinal absorption with the ipowder® than with ground dry leaves, manifested by a three-fold reduction in the quantity of ingested product needed for delivery of the same amount of rosmarinic acid into the upper gastro-intestinal tract. This study shows that the ipowder® technology preserves all the original plant compounds intact while making some active ingredients more accessible and available to exert their effects. To obtain a given effect, the amount of ipowder® extract to ingest will therefore be lower; a reduction in the daily dosage will be more convenient for the patient and will improve patient compliance with supplementation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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