Factors associated with biomedical research participation within community-based samples across 3 National Cancer Institute-designated cancer centers.

Autor: Barrett NJ; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.; Department of Community and Family Medicine, Duke School of Medicine, Durham, North Carolina.; Duke Clinical and Translational Science Institute, Duke University School of Medicine, Durham, North Carolina., Rodriguez EM; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Iachan R; ICF, Rockville, Maryland., Hyslop T; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina., Ingraham KL; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Le GM; Center for Vulnerable Populations, Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, San Francisco, California., Martin K; ICF, Rockville, Maryland., Haring RC; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Rivadeneira NA; Center for Vulnerable Populations, Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, San Francisco, California.; Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, San Francisco, California., Erwin DO; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Fish LJ; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Middleton D; ICF, Rockville, Maryland., Hiatt RA; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California.; Department of Epidemiology and Biostatistics, School of Medicine, University of California at San Francisco, San Francisco, California., Patierno SR; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina., Sarkar U; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California., Gage-Bouchard EA; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2020 Mar 01; Vol. 126 (5), pp. 1077-1089. Date of Electronic Publication: 2020 Jan 07.
DOI: 10.1002/cncr.32487
Abstrakt: Background: Engaging diverse populations in biomedical research, including biospecimen donation, remains a national challenge. This study examined factors associated with an invitation to participate in biomedical research, intent to participate in biomedical research in the future, and participation in biomedical research and biospecimen donation among a diverse, multilingual, community-based sample across 3 distinct geographic areas.
Methods: Three National Cancer Institute-designated cancer centers engaged in community partnerships to develop and implement population health assessments, reaching a convenience sample of 4343 participants spanning their respective catchment areas. Data harmonization, multiple imputation, and multivariable logistic modeling were used.
Results: African Americans, Hispanic/Latinos, and other racial minority groups were more likely to be offered opportunities to participate in biomedical research compared to whites. Access to care, history of cancer, educational level, survey language, nativity, and rural residence also influenced opportunity, intent, and actual participation in biomedical research.
Conclusions: Traditionally underserved racial and ethnic groups reported heightened opportunity and interest in participating in biomedical research. Well-established community partnerships and long-standing community engagement around biomedical research led to a diverse sample being reached at each site and may in part explain the current study findings. However, this study illustrates an ongoing need to establish trust and diversify biomedical research participation through innovative and tailored approaches. National Cancer Institute-designated cancer centers have the potential to increase opportunities for diverse participation in biomedical research through community partnerships and engagement. Additional work remains to identify and address system-level and individual-level barriers to participation in both clinical trials and biospecimen donation for research.
(© 2020 American Cancer Society.)
Databáze: MEDLINE
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