One-Pot Assembly of 3-Hydroxycarbazoles via Uninterrupted Propargylation/Hydroxylative Benzannulation Reactions.

Autor:	Raji Reddy C; Department of Organic Synthesis & Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201 002 , India., Subbarao M; Department of Organic Synthesis & Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201 002 , India., Sathish P; Department of Organic Synthesis & Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201 002 , India., Kolgave DH; Department of Organic Synthesis & Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201 002 , India., Donthiri RR; Department of Organic Synthesis & Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
Jazyk:	angličtina
Zdroj:	Organic letters [Org Lett] 2020 Jan 17; Vol. 22 (2), pp. 689-693. Date of Electronic Publication: 2020 Jan 07.
DOI:	10.1021/acs.orglett.9b04472
Abstrakt:	A novel strategy for the synthesis of 3-hydroxycarbazoles involving the consecutive propargylation/palladium-catalyzed hydroxylative benzannulation of indole-2-carbonyls with propargylic alcohols has been exploited. This one-pot procedure leads to a wide range of substituted 3-hydroxycarbazoles in high yield with a broad substrate scope. The method was further extended to access furano-carbazole derivatives from dialkynols via tandem annulations.
Databáze:	MEDLINE
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