808 nm Near-Infrared Light-Excited UCNPs@mSiO 2 -Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer.

Autor: Hu J; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., Shi J; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China.; Department of Surgery, VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 12132, USA., Gao Y; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., Yang W; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., Liu P; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., Liu Q; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., He F; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China., Wang C; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China., Li T; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People's Republic of China., Xie R; Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People's Republic of China., Zhu J; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People's Republic of China., Yang P; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China.
Jazyk: angličtina
Zdroj: International journal of nanomedicine [Int J Nanomedicine] 2019 Dec 20; Vol. 14, pp. 10009-10021. Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019).
DOI: 10.2147/IJN.S221496
Abstrakt: Background: It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment.
Purpose: We aimed to investigate 808 nm NIR light-excited UCNPs@mSiO 2 -Ce6-GPC3 nanocomposites for PDT in liver cancer.
Methods: In our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking UCNPs@mSiO 2 -Ce6-GPC3 nanoparticles under 808 nm laser irradiation with enhanced depth of penetration would enable the effective targeting of PDT.
Results: We found that the UCNPs@mSiO 2 -Ce6-GPC3 nanoparticles had good biocompatibility, low toxicity, excellent cell imaging in HepG2 cancer cells and high anti-tumor effect in vitro and in vivo.
Conclusion: We believe that the utilization of 808 nm NIR excited UCNPs@mSiO 2 -Ce6-GPC3 nanoparticles for PDT is a safe and potential therapeutic option for liver cancer.
Competing Interests: The authors have no conflicts of interest to disclose.
(© 2019 Hu et al.)
Databáze: MEDLINE
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