Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015.

Autor: Donneborg ML; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark. mld@rn.dk.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. mld@rn.dk., Hansen BM; Department of Pediatrics, Herlev Hospital, Copenhagen, Denmark., Vandborg PK; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark., Rodrigo-Domingo M; Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Psychiatry, Aalborg University Hospital, Aalborg, Denmark., Ebbesen F; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2020 Feb; Vol. 40 (2), pp. 194-202. Date of Electronic Publication: 2020 Jan 06.
DOI: 10.1038/s41372-019-0566-8
Abstrakt: Objective: To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015.
Study Design: We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases.
Result: We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology.
Conclusions: Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
Databáze: MEDLINE
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