| Autor: |
Ribeiro DML; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Carvalho Júnior AR; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Vale de Macedo GHR; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Chagas VL; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Silva LDS; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Cutrim BDS; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Santos DM; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Soares BLL; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., Zagmignan A; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., de Miranda RCM; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil., de Albuquerque PBS; Departamento de Medicina, Universidade de Pernambuco, Garanhuns, Pernambuco 55294902, Brazil., Nascimento da Silva LC; Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075-120, Brazil. |
| Abstrakt: |
Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as Acinetobacter baumannii, Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus ) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections. Thus, the treatment of non-healing chronic wounds is a huge challenge for health services worldwide, imposing great socio-economic damage to the affected individuals. This scenario has encouraged the use of natural polymers, such as polysaccharide, in order to develop new formulations (membranes, nanoparticles, hydrogels, scaffolds) to be applied in the treatment of skin infections. In this non-exhaustive review, we discuss the applications of polysaccharide-based formulations in the healing of infected wounds in animal models and clinical trials. The formulations discussed in this review were prepared using alginate, cellulose, chitosan, and hyaluronic acid. In addition to have healing actions per se , these polysaccharide formulations can act as transdermal drug delivery systems, controlling the release of active ingredients (such as antimicrobial and healing agents). The papers show that these polysaccharides-based formulations are efficient in controlling infection and improve the healing, even in chronic infected wounds. These data should positively impact the design of new dressings to treat skin infections. |
