Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius .

Autor:	Smyrniotopoulos V; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece., de Andrade Tomaz AC; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.; Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil., Vanderlei de Souza MF; Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil., Leitão da Cunha EV; Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil., Kiss R; Fonds National de la Recherche Scientifique, 1050 Bruxelles, Belgium., Mathieu V; Department of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium.; ULB Cancer Research Center, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium., Ioannou E; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece., Roussis V; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Jazyk:	angličtina
Zdroj:	Marine drugs [Mar Drugs] 2019 Dec 29; Vol. 18 (1). Date of Electronic Publication: 2019 Dec 29.
DOI:	10.3390/md18010029
Abstrakt:	Eight new ( 1 - 8 ) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC 50 values 15 and 16 μM, respectively.
Databáze:	MEDLINE
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