Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma.

Autor:	Sakurai K; Fujita Health University School of Medicine, Department of Diagnostic Pathology, Toyoake, Aichi, Japan, 470-1192. uranom@fujita-hu.ac.jp., Onouchi T, Yamada S, Baba Y, Murata T, Tsukamoto T, Kuroda M, Urano M
Jazyk:	angličtina
Zdroj:	The Malaysian journal of pathology [Malays J Pathol] 2019 Dec; Vol. 41 (3), pp. 339-343.
Abstrakt:	Introduction: Cribriform-morular variant (CMV) is a rare variant of papillary thyroid carcinoma. It frequently occurs in association with familial adenomatous polyposis (FAP), although some cases are sporadic. Herein, we report a case of CMV and analyse morule cytohistology. Case Report: The patient was a 47-year-old woman with no familial history of FAP. A 3.0-cm unifocal mass was identified in the left thyroidal lobe. Fine-needle aspiration cytology revealed papillary clusters of atypical cells with nuclear grooves, which was suspected to be conventional papillary thyroid carcinoma. Histologically, the tumour comprised a papillary and cribriform growth of atypical cells with cytoplasmic accumulation and nuclear translocation of b-catenin. In addition, frequent morule formation was identified. Discussion: In this case, we performed morule analysis through correlative light and electron microscopy (CLEM), and revealed its ultrastructure. Although CMV is a rare form of thyroid carcinoma, it should be considered along with its distinct clinicopathological characteristics.
Databáze:	MEDLINE
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