Risk of diabetes among related and unrelated family members.

Autor: Aasbjerg K; Department of Ophthalmology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark; Aalborg University Hospital, Unit of Epidemiology and Biostatistics, Hobrovej 18-22, PO-box 365, DK-9000 Aalborg, Denmark. Electronic address: kristian@aasbjerg.dk., Nørgaard CH; Department of Cardiology and Clinical Research, Nordsjællands University Hospital, Hillerød, Denmark., Vestergaard N; Department of Ophthalmology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark; Aalborg University Hospital, Unit of Epidemiology and Biostatistics, Hobrovej 18-22, PO-box 365, DK-9000 Aalborg, Denmark., Søgaard P; Department of Cardiology, Aalborg University Hospital, DK-9000 Aalborg, Denmark., Køber L; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark., Weeke P; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark., Gislason G; Copenhagen University Hospital Herlev and Gentofte, Department of Cardiology, Kildegårdsvej 28, DK-2900 Hellerup, Denmark; The Danish Heart Foundation, Vognmagergade 7, 1120 Copenhagen, Denmark; The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Torp-Pedersen C; Department of Cardiology and Clinical Research, Nordsjællands University Hospital, Hillerød, Denmark.
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2020 Feb; Vol. 160, pp. 107997. Date of Electronic Publication: 2019 Dec 31.
DOI: 10.1016/j.diabres.2019.107997
Abstrakt: Aims: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.
Methods: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.
Results: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.
Conclusions/interpretation: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.
Competing Interests: Declaration of Competing Interest The authors have no duality of interest to declare in the present context. Gunnar Gislason is a minor shareholder of Novo Nordisk.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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