| Autor: |
Stafford KC 3rd; Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA., Williams SC; Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA. scott.williams@ct.gov., van Oosterwijk JG; U.S. Biologic, Inc., Memphis, TN, USA., Linske MA; Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA., Zatechka S; U.S. Biologic, Inc., Memphis, TN, USA., Richer LM; U.S. Biologic, Inc., Memphis, TN, USA., Molaei G; Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA.; Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA., Przybyszewski C; U.S. Biologic, Inc., Memphis, TN, USA., Wikel SK; U.S. Biologic, Inc., Memphis, TN, USA.; Department of Medical Sciences, School of Medicine, Quinnipiac University, Hamden, CT, USA. |
| Abstrakt: |
Blacklegged ticks (Ixodes scapularis) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice (Peromyscus leucopus) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were previously developed and successfully evaluated in laboratory and controlled field trials. A novel, inactivated RTV was developed to minimize regulatory and market challenges facing previous RTVs based on live bacterial or viral vehicles. Thirty-two residential properties in Redding, Connecticut, participated in a field trial of an orally delivered, inactivated RTV efficacy study (2015-2016). During the two-year vaccination period, a significant decrease in the percentage of B. burgdorferi-infected I. scapularis larvae parasitizing P. leucopus was observed, as was a significant reduction in the percentage of infected P. leucopus on RTV-treated properties when compared to control properties. This novel inactivated RTV was effective in reducing numbers of B. burgdorferi-infected I. scapularis and B. burgdorferi-infected P. leucopus on properties where it was distributed. |
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