| Autor: |
Chou WY; Graduate Institute of Life Sciences., Lai PY; School of Public Health., Hu JM; Graduate Institute of Medical Sciences.; Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital.; School of Medicine., Hsu CH; Graduate Institute of Medical Sciences.; Teaching Office, Tri-Service General Hospital, National Defense Medical Center, Taipei City., Chen YC; Department of Medicine.; Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City., Tian YF; Division of Colorectal Surgery, Department of Surgery, Chi-Mei Medical Center.; Department of Health & Nutrition, Chia Nan University of Pharmacy and Science, Tainan City., You SL; Department of Medicine.; Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City., Hsiao CW; Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital., Chou YC; Graduate Institute of Life Sciences.; School of Public Health., Sun CA; Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City.; Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. |
| Abstrakt: |
The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008. Follow-up time was calculated from the date of entry in the cohort until the occurrence of a first CRC diagnosis, death, or the end of the observation period (December 31, 2013), whichever occurred first. Hazards ratios (HRs) and accompanying 95% confidence intervals (CIs) derived from the Fine-Gray competing risk model were used to estimate the association between AD and CRC risk. After multivariable adjustment, AD was associated with an increased risk of CRC (adjusted HR, 1.26; 95% CI, 1.14-1.40). Of note, a significant positive association between AD and CRC risk was evident in both men and women and in all age groups. In summary, this population-based cohort study revealed that AD was associated with an increased risk of CRC in an Asian population. It will be of interest for cohort studies with prediagnostic specimens to evaluate the potential relationship between AD and CRC using biomarkers for allergy status. |
