Elite suppressors have low frequencies of intact HIV-1 proviral DNA.

Autor:	Kwaa AK; Department of Medicine, Center For AIDS Research, Johns Hopkins Medicine., Garliss CC; Department of Medicine, Center For AIDS Research, Johns Hopkins Medicine., Ritter KD; Accelevir Diagnostics, Baltimore, Maryland, USA., Laird GM; Accelevir Diagnostics, Baltimore, Maryland, USA., Blankson JN; Department of Medicine, Center For AIDS Research, Johns Hopkins Medicine.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2020 Mar 15; Vol. 34 (4), pp. 641-643.
DOI:	10.1097/QAD.0000000000002474
Abstrakt:	: Elite controllers or suppressors control viral replication without antiretroviral therapy. We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in elite suppressors and found that, while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors on antiretroviral therapy there was no significant difference in the ratio of intact to total proviral DNA between elite suppressors and chronic progressors.
Databáze:	MEDLINE
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