Improvements in Skeletal Muscle Can Be Detected Using Broadband NIRS in First-Time Marathon Runners.

Autor: Jones S; MRC Unit for Lifelong Health & Ageing at UCL, Department of Population Science & Experimental Medicine, Institute for Cardiovascular Science, UCL, London, UK., Kinsella M; Medical Physics and Biomedical Engineering, University College London, London, UK., Torlasco C; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Kaynezhad P; Medical Physics and Biomedical Engineering, University College London, London, UK., de Roever I; Medical Physics and Biomedical Engineering, University College London, London, UK., Moon JC; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Hughes AD; MRC Unit for Lifelong Health & Ageing at UCL, Department of Population Science & Experimental Medicine, Institute for Cardiovascular Science, UCL, London, UK., Bale G; Medical Physics and Biomedical Engineering, University College London, London, UK. g.bale@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Advances in experimental medicine and biology [Adv Exp Med Biol] 2020; Vol. 1232, pp. 245-251.
DOI: 10.1007/978-3-030-34461-0_31
Abstrakt: Skeletal muscle metabolic function is known to respond positively to endurance exercise interventions, such as marathon training. Studies investigating skeletal muscle have typically used muscle biopsy samples or magnetic resonance spectroscopy (MRS) to interrogate metabolic function. We aimed to non-invasively detect exercise-training-induced improvements in muscle function using broadband near-infrared spectroscopy (NIRS). We used NIRS to determine concentration changes in oxygenated haemoglobin (HbO 2 ) and the oxidation state of cytochrome-c-oxidase (oxCCO) in gastrocnemius during arterial occlusion in 14 volunteers. We also used a cardio-pulmonary exercise test (CPET) to assess peak total body oxygen uptake (peakVO 2 ; a measure of fitness). Measurements were made at baseline (BL) which was prior to a period of at least 16 weeks of training for the 2017 London Marathon, and then within 3 weeks after completion of the marathon, follow-up (FU). We observed an increase in locally measured muscle oxygen consumption and rate of oxCCO concentration change, but not in cardio-respiratory fitness measured as whole-body peak oxygen consumption (peakVO 2 ).
Databáze: MEDLINE
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