Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury.

Autor: Bale G; Medical Physics and Biomedical Engineering, University College London, London, UK. g.bale@ucl.ac.uk., Taylor N; Medical Physics and Biomedical Engineering, University College London, London, UK., Mitra S; Institute for Women's Health, University College London, London, UK., Sudakou A; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland., de Roever I; Medical Physics and Biomedical Engineering, University College London, London, UK., Meek J; Institute for Women's Health, University College London, London, UK., Robertson N; Institute for Women's Health, University College London, London, UK., Tachtsidis I; Medical Physics and Biomedical Engineering, University College London, London, UK.
Jazyk: angličtina
Zdroj: Advances in experimental medicine and biology [Adv Exp Med Biol] 2020; Vol. 1232, pp. 3-9.
DOI: 10.1007/978-3-030-34461-0_1
Abstrakt: Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO 2 ) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick's principle and uses HbD as a tracer; when a sudden change in SaO 2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g -1  min -1 with a range of 4 ml 100 g -1  min -1 to 60 ml 100 g -1  min -1 . For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth.
Databáze: MEDLINE
Externí odkaz: