Late Growth and Changes in Body Composition Influence Odds of Developing Retinopathy of Prematurity among Preterm Infants.

Autor:	Ingolfsland EC; Department of Pediatrics, University of Minnesota, Minneapolis, East Building 6th floor, MB630, 2450 Riverside Ave, Minneapolis, MN 55454, USA., Haapala JL; Division of Epidemiology and Community Health, University of Minnesota, 300 West Bank Office Building, 1300 S 2nd St, Minneapolis, MN 55454, USA., Buckley LA; Department of Pediatrics, University of Minnesota, Minneapolis, East Building 6th floor, MB630, 2450 Riverside Ave, Minneapolis, MN 55454, USA., Demarath EW; Division of Epidemiology and Community Health, University of Minnesota, 300 West Bank Office Building, 1300 S 2nd St, Minneapolis, MN 55454, USA., Guiang SF; Department of Pediatrics, University of Minnesota, Minneapolis, East Building 6th floor, MB630, 2450 Riverside Ave, Minneapolis, MN 55454, USA., Ramel SE; Department of Pediatrics, University of Minnesota, Minneapolis, East Building 6th floor, MB630, 2450 Riverside Ave, Minneapolis, MN 55454, USA.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2019 Dec 27; Vol. 12 (1). Date of Electronic Publication: 2019 Dec 27.
DOI:	10.3390/nu12010078
Abstrakt:	Background: While postnatal growth in the first month of life is known to impact retinopathy of prematurity (ROP) risk, the impact of growth later in hospitalization, during critical times of retinal vascularization, remains unknown. The purpose of this study was to assess if postnatal growth and body composition during the second half of neonatal intensive care unit hospitalization were associated with severity of retinopathy of prematurity in very low birth weight preterm infants. Methods: Prospective observational pilot study of 83 infants born <32 weeks gestation and <1500 g, conducted at a Level IV neonatal intensive care unit. Body composition was measured during the second half of hospitalization. Infants were evaluated for retinopathy of prematurity. Logistic regression was performed. Results: Greater gains in fat mass, fat-free mass, and percent body fat from 32 to 37 weeks postmenstrual age and higher % body fat at term postmenstrual age were associated with decreased odds of ≥stage 2 retinopathy of prematurity ( p < 0.05). Conclusions: Improved growth later in neonatal intensive care unit hospitalization and increased adiposity at term may reduce odds of severe retinopathy of prematurity.
Databáze:	MEDLINE
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