Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series.

Autor: Serpa SC; Department of Pediatric Neurology, SOS Neuro Clinic, Recife, Brazil., de Melo ACMG; Department of Pediatric Neurology, Hospital da Restauração, Recife, Brazil., Gomes Lins O; Department of Pediatric Neurology, SOS Neuro Clinic, Recife, Brazil., van der Linden V; Department of Pediatric Neurology, Hospital Barão de Lucena, Recife, Brazil., Leite Rolim Filho E; Department of Pediatric Orthopedic, Hospital Getúlio Vargas, Recife, Brazil., Oliveira Dos Santos AC; Post-graduate Program in Health Sciences, Universidade de Pernambuco, Recife, Brazil.
Jazyk: angličtina
Zdroj: Birth defects research [Birth Defects Res] 2020 Mar; Vol. 112 (5), pp. 385-392. Date of Electronic Publication: 2019 Dec 31.
DOI: 10.1002/bdr2.1641
Abstrakt: Background: Congenital arthrogryposis (CA) consists of congenital joint contractures that affect at least two joints in different parts of the body. Approximately, 80% of CA cases are neurogenic, with changes to the formation, structure or functioning of the central and/or peripheral nervous systems. Most abnormalities are triggered either by motoneurons decreased activation in the corticospinal tract or by direct motoneurons injury. There had been few reports in the literature correlating congenital infection in humans with arthrogryposis until 2015. CA has recently been described associated with congenital Zika syndrome (CZS).
Methods: The objective of this study was to investigate and describe accurately the arthrogrypotic alterations in infants diagnosed with CZS and thus, suggest a possible pattern of orthopedic impairment. A total of 198 medical records of infants with CZS were evaluated. According to inclusion and exclusion criteria, 17 infants were included in the present study. Arthrogrypotic joints were orthopedically evaluated in four segments: right, left, upper, and lower limbs. All the four segments were assessed independently.
Results: Flexed wrists were the most frequently observed manifestation, associated with ulnar deviation (35.29%). Deformities were also commonly found in the third and fourth fingers (64.70%). Hip dislocation was found in 58.82% of the patients and talipes equinovarus and equinovalgus ankles were found in 29.41 and 23.52%.
Conclusion: There was a particular pattern of joint impairment related to CZS and arthogrypotic alterations of infants evaluated in this study.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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