A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study.

Autor: Marin-Barrera L; Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain., Muñoz-Martin AJ; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain., Rios-Herranz E; Hematology and Hemotherapy Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, Spain., Garcia-Escobar I; Medical Oncology Department, HGU de Ciudad Real, 13003 Ciudad Real, Spain., Beato C; Medical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain., Font C; Medical Oncology Department, DIBAPS/Translational Genomics and Targeted Therapeutics in Solid Tumors, Hospital Clínic, 08036 Barcelona, Spain., Oncala-Sibajas E; Emergency Department, Hospital Virgen Macarena, 41009 Sevilla, Spain., Revuelta-Rodriguez A; Medical Oncology Department, Hospital Universitario Central de Asturias, 33611 Oviedo, Spain., Areses MC; Medical Oncology Department, Hospital de Orense, 32616 Orense, Spain., Rivas-Jimenez V; Medical Oncology Department, Hospital de Jerez de la Frontera, 11407 Cádiz, Spain., Moreno-Santos MA; Medical Oncology Department, H. U. Puerto Real, 11510 Cádiz, Spain., Ballaz-Quincoces A; Respiratory Department, Hospital de Galdakao-Usansolo, 48960 Bizkaia, Spain., Lopez-Saez JB; Internal Medicine Unit. H. U. Puerto Real, 11510 Cádiz, Spain., Gallego I; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain., Elias-Hernandez T; Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain., Asensio-Cruz MI; Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain., Chasco-Eguilaz L; Respiratory Department, Hospital de Galdakao-Usansolo, 48960 Bizkaia, Spain., Garcia-Gonzalez G; Medical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain., Estevez-Garcia P; Medical Oncology Department, Hospital Virgen del Rocio, 41013 Sevilla, Spain., Otero R; Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain., Lima-Alvarez J; Respiratory Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, Spain., Jara-Palomares L; Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2019 Dec 26; Vol. 12 (1). Date of Electronic Publication: 2019 Dec 26.
DOI: 10.3390/cancers12010075
Abstrakt: Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer-particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: -0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: -10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: -21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: -9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.
Databáze: MEDLINE
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