Influence of Resveratrol on Oxidation Processes and Lipid Phase Characteristics in Damaged Somatic Nerves.

Autor: Pinyaev SI; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Kuzmenko TP; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Revina NV; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Parchaykina MV; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Pronin AS; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Syusin IV; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Novozhilova OS; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Revin VV; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Chudaikina EV; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia., Revina ES; Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, Saransk, Russia.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2019 Dec 11; Vol. 2019, pp. 2381907. Date of Electronic Publication: 2019 Dec 11 (Print Publication: 2019).
DOI: 10.1155/2019/2381907
Abstrakt: It has been shown that the intensification of oxidative processes is observed when somatic nerves of rats are damaged. Accumulation of malondialdehyde occurs, and the phase properties of the lipid bilayer change, especially in the distal part of the nerve. Under the same conditions, there are multidirectional changes in the activity of antioxidant enzymes, superoxide dismutase (SOD) activity decreases, and catalase (CAT) activity increases. Under the action of resveratrol, there is a decrease in the number of TBA-active products in both areas of the damaged nerve. Alongside resveratrol action, SOD and CAT activity tends to return towards the control values. Similar patterns are observed in the action of resveratrol on the phase states of lipids with the damage to somatic nerves. By summarizing the data obtained, it can be claimed that when the nerve is damaged, profound changes occur both in the lipid component and in the antioxidant system. Resveratrol has a stabilizing effect on the studied parameters, and a longer period of time is required for their complete recovery.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2019 S. I. Pinyaev et al.)
Databáze: MEDLINE
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