Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects.

Autor:	Ferreira SBS; Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil., Braga G; Department of Chemistry, State University of Maringa, Maringa, Brazil., Oliveira ÉL; Department of Chemistry, State University of Maringa, Maringa, Brazil., da Silva JB; Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil., Rosseto HC; Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil., de Castro Hoshino LV; Department of Physics, State University of Maringa, Maringa, Brazil., Baesso ML; Department of Physics, State University of Maringa, Maringa, Brazil., Caetano W; Department of Chemistry, State University of Maringa, Maringa, Brazil., Murdoch C; The School of Clinical Dentistry, The University of Sheffield, Sheffield, UK., Colley HE; The School of Clinical Dentistry, The University of Sheffield, Sheffield, UK., Bruschi ML; Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil.
Jazyk:	angličtina
Zdroj:	Beilstein journal of nanotechnology [Beilstein J Nanotechnol] 2019 Nov 25; Vol. 10, pp. 2304-2328. Date of Electronic Publication: 2019 Nov 25 (Print Publication: 2019).
DOI:	10.3762/bjnano.10.222
Abstrakt:	Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P ® have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were elucidated by incorporation kinetics and location studies. They revealed that the drug was quickly incorporated and located in the hydrophobic portion of nanometer-sized polymeric micelles. Moreover, the systems displayed plastic behavior with rheopexy characteristics at 37 °C, viscoelastic properties and a gelation temperature of 36 °C, which ensures increased retention after application in the oral cavity. The mucoadhesion results confirmed the previous findings with the nanostructured systems showing a residence time of 20 min in porcine oral mucosa under flow system conditions. Curcumin was released after 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while selectivity targeting cancer cells. (Copyright © 2019, Ferreira et al.; licensee Beilstein-Institut.)
Databáze:	MEDLINE
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