Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement.

Autor:	Heymann G; Department of Psychiatry, University of Washington, Seattle, WA 98195, USA., Jo YS; Department of Psychiatry, University of Washington, Seattle, WA 98195, USA; Department of Psychology, Korea University, Seoul 02841, Republic of Korea., Reichard KL; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA., McFarland N; Department of Psychiatry, University of Washington, Seattle, WA 98195, USA., Chavkin C; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA., Palmiter RD; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Soden ME; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA., Zweifel LS; Department of Psychiatry, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: larryz@uw.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2020 Mar 04; Vol. 105 (5), pp. 909-920.e5. Date of Electronic Publication: 2019 Dec 23.
DOI:	10.1016/j.neuron.2019.11.024
Abstrakt:	Dopamine neurons of the ventral tegmental area (VTA) regulate reward association and motivation. It remains unclear whether there are distinct dopamine populations to mediate these functions. Using mouse genetics, we isolated two populations of dopamine-producing VTA neurons with divergent projections to the nucleus accumbens (NAc) core and shell. Inhibition of VTA-core-projecting neurons disrupted Pavlovian reward learning, and activation of these cells promoted the acquisition of an instrumental response. VTA-shell-projecting neurons did not regulate Pavlovian reward learning and could not facilitate acquisition of an instrumental response, but their activation could drive robust responding in a previously learned instrumental task. Both populations are activated simultaneously by cues, actions, and rewards, and this co-activation is required for robust reinforcement of behavior. Thus, there are functionally distinct dopamine populations in the VTA for promoting motivation and reward association, which operate on the same timescale to optimize behavioral reinforcement. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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