Direct Decarboxylative Functionalization of Carboxylic Acids via O-H Hydrogen Atom Transfer.
| Autor: | Na CG; Department of Chemistry , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States., Ravelli D; PhotoGreen Lab, Department of Chemistry , University of Pavia , Viale Taramelli 12 , 27100 Pavia , Italy., Alexanian EJ; Department of Chemistry , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Chemical Society [J Am Chem Soc] 2020 Jan 08; Vol. 142 (1), pp. 44-49. Date of Electronic Publication: 2019 Dec 26. |
| DOI: | 10.1021/jacs.9b10825 |
| Abstrakt: | Decarboxylative functionalization via hydrogen atom transfer offers an attractive alternative to standard redox approaches to this important class of transformations. Herein, we report a direct decarboxylative functionalization of aliphatic carboxylic acids using N -xanthylamides. The unique reactivity of amidyl radicals in hydrogen atom transfer enables decarboxylative xanthylation under redox-neutral conditions. This platform provides expedient access to a range of derivatives through subsequent elaboration of the xanthate group. |
| Databáze: | MEDLINE |
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