Microglial microRNAs mediate sex-specific responses to tau pathology.

Autor: Kodama L; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, NY, New York, USA.; Medical Scientist Training Program and Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Guzman E; Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.; Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA., Etchegaray JI; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Li Y; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Sayed FA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Zhou L; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA., Zhou Y; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Zhan L; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Le D; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Udeochu JC; Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, NY, New York, USA., Clelland CD; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Neurobiology, University of California, San Francisco, San Francisco, CA, USA., Cheng Z; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA., Yu G; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA., Li Q; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA., Kosik KS; Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.; Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA., Gan L; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA. lig2033@med.cornell.edu.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA. lig2033@med.cornell.edu.; Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, NY, New York, USA. lig2033@med.cornell.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2020 Feb; Vol. 23 (2), pp. 167-171. Date of Electronic Publication: 2019 Dec 23.
DOI: 10.1038/s41593-019-0560-7
Abstrakt: Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
Databáze: MEDLINE